Prasannakumar Deshpande, Dani Flinkman, Ye Hong, Elena Goltseva, Valentina Siino, Lihua Sun, Sirkku Peltonen, Laura Elo, Valtteri Kaasinen, Peter James, Eleanor T. Coffey. Protein synthesis is suppressed in sporadic and familial Parkinson’s Disease by LRRK2. bioRxiv 2020. Preprint

Emilia Komulainen, Artemis Varidaki, Natalia Kulesskaya, Hasan Mohammad, Christel Sourander, Heikki Rauvala, Eleanor T Coffey. Impact of JNK and its substrates on dendritic spine morphology. Cells 2020 in press.

Hollos P, John JM, Lehtonen, J, Coffey E. Optogenetic control of spine-head JNK reveals a role in dendritic spine regression. eNeuro 2020 Jan. Full text

David J, Gormley S, McIntosh AL, Kebede V, Thuery G, Varidaki A, Coffey ET, Harkin A. L-alpha-amino adipic acid provokes depression-like behaviour and a stress related increase in dendritic spine density in the pre-limbic cortex and hippocampus in rodents. Behav Brain Res. 2019 Apr 19;362:90-102. Full text

Hollos P, Marchisella F, Coffey ET. JNK Regulation of Depression and Anxiety. Brain Plast. 2018 Aug 10;3(2):145-155. Review. Full text

Varidaki A, Hong Y, Coffey ET. Repositioning Microtubule Stabilizing Drugs for Brain Disorders. Front Cell Neurosci. 2018 Aug 8;12:226. Review. Full text

Jadhav S, Gulumkar V, Deshpande P, Coffey ET, Lönnberg H, Virta P. Synthesis of Azide-Modified Chondroitin Sulfate Precursors: Substrates for “Click”- Conjugation with Fluorescent Labels and Oligonucleotides. Bioconjug Chem. 2018 Jul 18;29(7):2382-2393. Full text

Mohammad, H.#., Marchisella, F.#., Ortega-Martinez, S.#,Hollos, P., Eerola, K., Komulainen, E., Kulesskaya, N.Freemantle, E., Fagerholm, V., Savontaus, E., Rauvala, H., Peterson, B.D., van Praag, H., Coffey, E. JNK1 controls adult hippocampal neurogenesis and imposes cell autonomous control of anxiety behaviour from the neurogenic niche. Molecular Psychiatry 2016; doi: 10.1038/mp.2016.203 #equal contribution View PDF Pubmed In the news

Marchisella, F., Coffey, E.T. *, Hollos, P. Microtubule and microtubule associated protein anomalies in psychiatric disorders. Cytoskeleton (Hoboken). Special review issue on Emerging Concepts in Neuronal Cytoskeleton. 2016;73(10):596-611. Pubmed

Padzik, A.#, Deshpande, P.#, Hollos, P.#, Franker, M., Rannikko, E., Cai, D., Prus, P., Mågard, M., Westerlund, N., Verhey, K., James, P., Hoogenraad, C., Coffey, ET. KIF5C S176 phosphorylation regulates microtubule binding and transport efficiency in neurons. Frontiers in Cellular Neuroscience. 2016;10:57  #equal contribution View PDF Pubmed

Varidaki, A., Mohammad, H., Coffey, ET. Molecular Mechanisms of Depression. In: Frodl, T., Systems Neuroscience in Depression. 1st ed. Elsevier;2016 p.143-163 Go to page

Ortega-Martinez, S. A new perspective on the role of CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis. Frontiers in Molecular Neuroscience. 2015; 8:46 View PDF Pubmed

Komulainen, E, Zdrojewska, J, Freemantle, E, Mohammad, H, Marchisella, F, Kulesskaya, N, Mysore, R, Deshpande, P, Michelson, K, Måberg, M, Rauvala, H, James, P, Coffey, E. JNK1 controls dendritic field size in L2/3 and L5 of the motor cortex, constrains soma size and influences fine motor coordination. Frontiers in Cellular Neuroscience. 2014 ;8:272          View PDF Pubmed

Coffey E.T.  Nuclear and cytosolic JNK signalling in neurons. Nature Reviews Neuroscience 2014; 15(5):285-99. Review Pubmed

Zdrojewska J, Coffey ET. The impact of JNK on neuronal migration. Advances in Experimental Medical Biology. 2014;800:37-57. Review. Pubmed

Trehan, A., Rotgers, E., Coffey, ET., Huhtaniemi, I., Rivero-Müller, A. CANDLES, an assay for monitoring GPCR induced cAMP generation in cell cultures. Cell Communication and Signaling. 2014;4;12:70 View PDF Pubmed

Björkblom, B.*, Padzik, A.*, Mohammad, H., Westerlund, N., Komulainen, E., Hollos, P., Parviainen, L., Papageorgiou, AC., Iljin, K., Kallioniemi, O., Kallajoki, M., Courtney, MJ., Mågård, M., James, P., Coffey, ET. JNK Phosphorylation of MARCKSL1 Determines Actin Stability and Migration in Neurons and in Cancer Cells. Molecular and Cellular Biology. 2012 32(17):3513-26. * equal contribution View PDF Pubmed

Jonsdottir, K., Zhang, H., Jhagroe, D., Skaland, I., Slewa, A., Björkblom, B., Coffey, ET., Gudlaugsson, E., Smaaland, R., Janssen, EA., Baak, JP. The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer. Breast Cancer Research and Treatment. 2012;135(2):381-90. Pubmed

Westerlund, N., Zdrojewska, J., Padzik, A., Komulainen, E., Björkblom, B., Rannikko, E., Tararuk, T., Garcia-Frigola, C., Sandholm, J., Nguyen, L., Kallunki, T., Courtney, MJ., Coffey ET. Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate. Nature Neuroscience. 2011;14(3):305-13. Pubmed In the news

Podkowa, M., Zhao, X., Chow, CW., Coffey, ET., Davis, RJ., Attisano, L. Microtubule stabilization by BMP receptor-mediated scaffolding of JNK promotes dendrite formation. Molecular and Cellular Biology. 2010;30(9):2241-50. View PDF Pubmed

Uusi-Oukari, M., Kontturi, LS., Coffey, ET., Kallinen, SA. AMPAR signaling mediating GABA(A)R delta subunit up-regulation in cultured mouse cerebellar granule cells. Neurochemistry International. 2010;57(2):136-42. Pubmed

Matlawska-Wasowska, K., Finn, R., Mustel, A., O’Byrne, CP., Baird, AW., Coffey, ET., Boyd, A. The vibrio parahaemolyticus Type III secretion systems manipulate host cell MAPK for critical steps in pathogenesis. BMC Microbiology. 2010;10:329. View PDF Pubmed

Morfini, GA., You, YM., Pollema, SL., Kaminska, A., Liu, K., Yoshioka, K., Björkblom, B., Coffey, ET., Bagnato, C., Han, D., Huang, CF., Banker, G., Pigino, G., Brady, ST. Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin.  Nature Neuroscience. 2009;12(7):864-71. View PDF Pubmed

Waetzig, V., Wacker, U., Haeusgen, W., Björkblom, B., Courtney, MJ., Coffey, ET. Herdegen, T. Concurrent protective and destructive signalling of JNK2 in neuroblastoma cells. Cellular Signalling. 2009;21(6):873-80. Pubmed

Naumanen, T., Johansen, LD., Coffey, ET., Kallunki, T. Loss of function of IKAP/ELP1: Could neuronal migration defect underlie familial disautonomia? Cell Adhesion and Migration. 2008;2(4):236-9.     View PDF Pubmed

Björkblom, B., Vainio, JC., Hongisto, V., Herdegen, T., Courtney, MJ., Coffey, ET. All JNKs can kill but nuclear localization is critical for neuronal death. Journal of Biological Chemistry. 2008;283(28)19704-13. View PDF Pubmed

Dan Johansen, L.,  Naumanen, T., Knudsen, A., Westerlund, N., Gromova, I., Junttila, M., Nielsen, C., Bottzauw, T., Tolkovsky, A., Westermarck, J., Coffey, ET., Jäättelä, M., Kallunki, T. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. Journal of Cell Science. 2008;121(6) 854-64. View PDF Pubmed

Hongisto, V., Vainio, JC., Thompson, R., Courtney, MJ., Coffey, ET. The Wnt pool of GSK-3-beta is critical for trophic deprivation induced neuronal death. Molecular and Cellular Biology. 2008;28(5)1515-27. View PDF Pubmed

Westerlund, N., Zdrojewska, J., Courtney, M.J., Coffey, E.T. SCG10 as a molecular effector of JNK1: Implications for the therapeutic targeting of JNK in nerve regeneration. Expert Opinion on Therapeutic Targets. 2008;12(1):31-43. Pubmed

Semenova, MM., Mäki-Hokkonen, AMJ., Cao, J., Komarovski, V., Forsberg, M., Koistinaho, M., Coffey, ET., Courtney, MJ. Rho mediates calcium-dependent activation of p38alpha and subsequent excitotoxic cell death. Nature Neuroscience. 2007;10,(4):436-443 Pubmed

Tararuk, R., Östman, N., Li, W., Björkblom, B., Padzik, A., Zdrojewska, J., Hongisto, V., Herdegen, T., Konopka, W., Courtney, MJ., Coffey, ET. JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length. Journal of Cell Biology. 2006;173(2):265-77 View PDF Pubmed

Björkblom, B., Östman, N., Hongisto, V., Komarovski, V., Filen, J., Nyman, T., Kallunki, T., Courtney, M., Coffey, E. Constitutively active cytoplasmic JNK1 is a dominant regulator of dendritic architecture; role of MAP2 as an effector. Journal of Neuroscience. 2005;25(27):6350-6361 View PDF Pubmed

Cao, J., Semenova, MM., Solovyan, VT., Han, J., Coffey, ET., Courtney, MJ. Distinct requirements for p38alpha and c-Jun N-terminal kinase stress-activated protein kinase s in different forms of apoptotic neuronal death. Journal of Biological Chemistry. 2004;279:35903-35913 View PDF Pubmed

Yang, J., Lindahl, M., Lindholm, P., Virtanen, H., Coffey, E., Runeberg-Roos, P., Saarma, M. PSPN/GFRalpha4 has a significantly weaker capacity than GDNF/GFRalpha1 to recruit RET to rafts, but promotes neuronal survival and neurite outgrowth. FEBS Letters. 2004;569:267-271 View PDF Pubmed

Hongisto, V., Smeds, N., Brecht, S., Herdegen, T., Courtney, MJ., Coffey, ET. Lithium blocks the c-Jun stress response and protects neurons via its action on glycogen synthase kinase 3. Molecular Cell Biology. 2003;23:6027-6036 View PDF Pubmed

Coffey, ET., Smiciene, G., Hongisto, V., Cao, J., Brecht, S., Herdegen, T., Courtney, MJ. c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons. Journal of  Neuroscience. 2002;22:4335-4345 View PDF Pubmed

Hietakangas, V., Elo, I., Rosenstrom, H., Coffey, ET., Kyriakis, JM., Eriksson, JE., Sistonen, L. Activation of the MKK4-JNK pathway during erythroid differentiation of K562 cells is inhibited by the heat shock factor 2-beta isoform. FEBS Letters. 2001;505:168-172 View PDF Pubmed

Courtney, MJ. and Coffey, ET. The mechanisms of Ara-C induced apoptosis of differentiating cerebellar granule neurons. European Journal of Neuroscience. 1999;11:1073-1084. Pubmed

Holmström, TH., Chow, SC., Elo, I., Coffey, ET., Orrenius, S., Sistonen, L., Eriksson, JE. Suppression of Fas/APO-1 mediated apoptosis by mitogen-activated kinase signaling. The Journal of Immunology. 1998;160(6):2626-36. View PDF Pubmed

Coffey, ET., Courtney. MJ. Regulation of SAPKs in CNS neurons. Biochemical Society Transactions. 1997;25(4):S568 Pubmed

Määttä, JA., Coffey, ET., Hermonen, JA., Salmi, AA., Hinkkanen, AE. Detection of myelin basic protein isoforms by organic concentrations. Biochemical and Biophysical Research Communications. 1997;238(2):498-502. Pubmed

Courtney, MJ., Åkerman, KEO. and Coffey, ET. Neurotrophins protect cultured cerebellar granule cells against the early phase of cell death by a two-component mechanism. Journal of Neuroscience. 1997;17, 4201-4211 View PDF Pubmed

Coffey, ET., Akerman, KE., Courtney, MJ. Brain derived neurotrophic factor induces a rapid upregulation of synaptophysin and tau proteins via the neurotrophin receptor TrkB in rat cerebellar granule cells. Neuroscience Letters. 1997;227:177-180 Pubmed

Coffey, ET., Sihra, TS., Nicholls, DG., Pocock, JM. Phosphorylation of synapsin I and MARCKS in nerve terminals is mediated by Ca2+ entry via and Aga-GI sensitive Ca2+ channels which is coupled to glutamate exocytosis. FEBS Letters. 1994;353(3):264-8 View PDF Pubmed

Coffey, ET., Herrero, I., Sihra, TS., Sánchez-Prieto, J., Nicholls, DG. Glutamate exocytosis and MARCKS phosphorylation are enhanced by a metabotropic glutamate receptor coupled to a protein kinase C synergistically activated by diacylglycerol and arachidonic acid. Journal of Neurochemistry. 1994;63(4):1303-10. Pubmed

Nicholls, DG., Coffey, ET. Glutamate exocytosis from isolated nerve terminals. Advanced Second Messenger Phosphoprotein Research. 1994;29:189-203. Pubmed

Coffey, ET., Sihra, TS., Nicholls, DG. Protein kinase C and the regulation of glutamate exocytosis from cerebrocortical synaptosomes. The Journal of Biological Chemistry. 1993;268(28):21060-5 View PDF Pubmed